This combination product (long-acting 2-agonist and inhaled corticosteroid) is recommended for routine treatment of asthma in the following cases:
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Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Bexitrol F 50/250 Bexicap should be used in pregnant women only if it is considered necessary by the doctor. Your doctor may prescribe this medicine after outweighing the risk and benefits to you and your baby. Therefore, inform your doctor before using it.
Bexitrol F 50/250 Bexicap should be used in breastfeeding women only if it is considered necessary by the doctor. Therefore, consult your doctor for advice before using it.
Do not drive or operate any heavy tools or machines if your ability is affected by Bexitrol F 50/250 Bexicap.
Bexitrol F 50/250 Bexicap should be taken with caution in patients with Kidney diseases. Therefore, consult your doctor before using it.
Bexitrol F 50/250 Bexicap should be taken with caution in patients with liver diseases. Therefore, consult your doctor before using it.
It is used to treat, prevent and manage the symptoms of:
Bexitrol F 50/250 Bexicap is a combination of two medicines namely, Fluticasone and Salmeterol. Fluticasone is an inhalation corticosteroid. It blocks the release of certain chemical messengers in the airways (such as prostaglandins, leukotrienes) that cause inflammation and swelling.
Salmeterol is a bronchodilator. It relaxes the smooth muscles of the airways and widens them. Collectively, they reduce airway inflammation, allow the air to pass through more freely, and make breathing easier.
Bexitrol F 50/250 Bexicap is a combination medicine containing Fluticasone and Salmeterol, which belongs to the groups of Corticosteroids and Bronchodilators respectively. It is used to treat asthma and COPD and also helps to reduce the flare-ups of COPD symptoms.
Asthma is a respiratory disease that causes the airways to become inflamed, swollen, and narrow, making it difficult for air to pass through. This results in symptoms like wheezing, breathing difficulties, chest pain, and coughing with excessive mucus secretion in the airways.
COPD is a lung disease that causes chronic inflammation and obstructed airflow in the airways, leading to symptoms such as wheezing, breathing difficulties, chest pain, and coughing with mucus production.
Salmeterol Xinafoate is a medication that belongs to the class of long-acting, selective beta-2 agonists. It is primarily used to treat asthma and other forms of airway obstruction. On the other hand, Fluticasone Propionate is a glucocorticoid and a type of corticosteroid that has primarily topical effects on the lungs at the recommended dosage.
Fluticasone Propionate helps in improving lung function and preventing exacerbations of the disease, while Salmeterol works to prevent symptoms. This combination of medications may provide a more convenient treatment regimen for patients who require concurrent therapy with a beta-2 agonist and inhaled corticosteroid.
The mechanism of action of Salmeterol involves binding to the exo-site of the beta-2-adrenoceptor, which is a selective, long-acting (12-hour) agonist.
The recommended dosages for inhalation aerosol and powder in capsule or Maxhaler forms vary depending on the age and condition of the patient. For adolescents and adults, the inhalation aerosol can be taken in 2 puffs of either 25g salmeterol and 50g fluticasone propionate, 25g salmeterol and 125g fluticasone propionate, or 25g salmeterol and 250g fluticasone propionate, twice daily. Children aged 4 to 12 can take 2 puffs of 25g salmeterol and 50g fluticasone propionate twice daily.
For inhalation powder in capsule form, the recommended dosages for adults and adolescents (12 years and older) are twice daily of either salmeterol 50g and fluticasone 100g or salmeterol 50g and fluticasone 250g, based on the severity of the patient's asthma. The maximum recommended dosage is salmeterol 50g and fluticasone 500g twice daily. For pediatric patients aged 4 to 11 with asthma, the recommended dosage is salmeterol 50g and fluticasone 100g twice daily.
For inhalation powder in Maxhaler form, the recommended dosages vary depending on the patient's age and condition. For adults and adolescents (12 years and older), one inhalation of either 50/100, 50/250, or 50/500 Maxhaler is recommended twice daily. For children aged 4 years and older, one inhalation of 50/100 Maxhaler twice daily is recommended. For COPD patients, one inhalation of Maxhaler twice daily is recommended.
Special patient groups: There is no need to adjust the dose in elderly or renal-impaired patients. There are no data on its use in patients with hepatic impairment. The Maxhaler is a user-friendly, ready-to-use, and easy-to-grip device. Follow the directions on the package.
Administration
Non-selective and selective -blockers should be avoided in asthma patients unless absolutely necessary. Because of the relatively low plasma concentrations obtained following inhalation treatment, clinically relevant medication interactions are unlikely. Fluticasone Propionate should be used with caution when combined with known strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) because there is a risk of increased systemic Fluticasone Propionate exposure.
This is not recommended for people who have had a history of hypersensitivity to any of the components.
Drug administration during pregnancy and breastfeeding should be undertaken only if the predicted benefit to the mother outweighs any potential harm to the fetus or child. There is inadequate data on the usage of Salmeterol Xinafoate and Fluticasone Propionate during pregnancy and lactation in humans. There is no information available about human breast milk.
Bexitrol F 50/250 Bexicap should be stored at room temperature, away from heat and direct light. It should be kept away from the reach of children and pets.
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